Definition of Obeticolic Acid

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What is the definition of Obeticolic Acid? Information about the definition of Obeticolic Acid.

Definition of Obeticolic Acid

Obeticolic acid is a synthetic acid used for the treatment of patients with primary biliary cirrhosis, or as it is now called “primary biliary cholangitis”. This receptor modulates the metabolic pathway of bile acids, fibrosis and inflammation, reducing the concentrations of bile acid in hepatocytes.

Definition of Obeticolic Acid

Primary biliary cholangitis is a rare disease that mostly affects women between 40 and 60 years. The causes that originate it are ignored but it is considered to be of the autoimmune type.

The application of this treatment in recent years has shown great progress, for those who do not respond with traditional therapy.

The authorization to apply this drug was given very recently (2016) by the US Food and Drug Administration (FDA).

The administration of obethicolic acid is by a dose of 10 mg once a day, causing a decrease in the concentrations of colic and chenodeoxycholic acid.

For the treatment of primary biliary cholangitis, the recommended dose in adults is 5 mg once a day. After three months, if an adequate decrease in alkaline phosphatase and / or total bilirubin has not yet been reached and the person is accepting the drug well, the dose can be increased to 10 mg once a day, this being the maximum dose recommended.

Among the side effects that could cause this drug are: abdominal pain, itching, dizziness, sore throat, peripheral edema, palpitations, abnormalities in the thyroid, among others.

It can be said then that it has been a great advance, the implementation of this drug, which comes to benefit patients with liver conditions for which there were few treatment options.

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